Determinants of Normal Left Atrial Volume in Heart Failure with Moderate-to-Severely Reduced Ejection Fraction

Table 3

Factors associated with change in LAVi.

Variable	6-month interval			1-year interval
	Estimate ± standard error	value	Variance	Estimate ± standard error	value	Variance
LVESVi	0.09 ± 0.02	<0.01	15%	0.09 ± 0.03	<0.01	11%
E	0.12 ± 0.03	<0.01	11%	0.16 ± 0.04	<0.01	13%
DT	−0.04 ± 0.01	<0.01	6%

Change in LVESVi and E were directly associated with change in LAVi at 6-month and 1-year follow-up, and DT was inversely associated with change in LAVi at 6-month follow-up. Total variance accounted for by the above factors was 32% at 6-month follow-up and 24% at 1-year follow-up. LVESVi, indexed left ventricular end-systolic volume; E, early mitral inflow velocity; DT, deceleration time; LAVi, indexed left atrial volume.