Disease Markers

Research Article

Ehlers-Danlos Syndrome, Hypermobility Type, Is Linked to Chromosome 8p22-8p21.1 in an Extended Belgian Family

Table 1

Clinical characteristics of affected and unaffected family members.
Age 
(years)		Beighton score (/9)Arthralgia(Sub) luxationCutaneousTendonitis, muscle crampsOtherStatus
CMPS >4 jointsCMPS 1–3 jointsEasy bruisingSoft skinSkin
hyperextensibility		Atrophic scarring/dilated scarsStriae
I.2755+ Hip, TMJ, and sternoclavicular joint++−+− Hernia umbilicalis, postoperative haemorrhages, and fragility of internal organsA
II.1472 +Ankles−−−++− U
II.2460−− −−−−−− NA
II.3456+  ++−−++Osteopenia, keratoconus, and muscle rupturesA
II.4445+ Fingers, TMJ++++++Discus herniaA
II.5439+ Generalized++−+++ A
II.6425+ Generalized++−−++ A
II.7363+ Shoulders, wrists, and patella++++++ A
II.8342−  −+/−−−+− U
II.9323−−Shoulder−−−+++− U
III.1240−− −−−−−− NA
III.2190−− −−−−−− NA
III.3190−− −−−−−− NA
III.4172−+Patella+−−−−− U
III.5152−− −−−−−− NA
III.6147− Fingers, ankles++++−− A
III.7102−  −−−−−− NA
III.899+ Wrist, toes+++−−−Transparent skinA
III.962−  −−−−−− NA
III.10189+ Fingers, patella++−+++ A
III.11116+  ++−−−− A
III.1297+  ++−−−− A
III.1372−− +/−+/−−−−− U
III.14119+ Ankles+++−−− A
III.15112−  −−−−−− NA
III.1676−− −+−+−− A
CMSP: chronic musculoskeletal pain for >3 months.
TMJ: temporomandibular joint.
A: “affected,” NA: “not affected,” and U: “unknown.”
Age at last clinical evaluation.