Review Article
Long Noncoding RNAs as Biomarkers in Cancer
Table 1
Upregulated cancer-associated lncRNAs when compared to normal tissues.
| Name | Cancer type | Fold changea | References |
| Wt1-as | Acute myeloid leukemia | NAb | [111] | XIST | Glioma | NA | [112] | CRNDE | Glioma | NA | [113] | MALAT1 | Glioma | 2.0–5.0 | [114] | | Colorectal | 2.0–6.0 | [115] | | Lung | >40.0 | [116] | | Prostate | NA | [84] | | Hepatocellular | NA | [117] | | Uterus | NA | [118] | LSINCT5 | Breast | 2.0–7.0 | [119] | LINC00617 | Breast | >1.5 | [120] | RP11-445H22.4 | Breast | 15.0–20.0 | [121] | BC200 | Breast | NA | [122] | CCHE1 | Cervical | NA | [123] | CCAT1-L | Colorectal | NA | [71] | POU3F3 | Esophageal | NA | [124] | PCAT-1 | Colorectal | NA | [125] | | Prostate | NA | [126] | HOTAIR | Esophageal | NA | [127] | | Lung | NA | [128] | | Cervical | NA | [129] | | Pancreas | NA | [130] | | Breast | NA | [52] | | Oral | NA | [131] | | Hepatocellular | >2.0 | [132] | | Glioma | NA | [133, 134] | | Colorectal | 5.2 | [101] | CCAT2 | Lung | 7.5 | [135] | | Colon | NA | [136] | | Cervical | NA | [137] | LINC00152 | Gastric | NA | [35, 90] | LSINCT-5 | Gastric | NA | [138] | HOXA11-AS | Glioma | NA | [139] | Linc-POU3F3 | Glioma | >2.6 | [140] | ATB | Glioma | 5.0–10.0 | [141] | AB073614 | Glioma | NA | [142] | RP11-160H22.5 | Hepatocellular | 2.5 | [109] | XLOC_014172 | Hepatocellular | 67.7 | [109] | LOC149086 | Hepatocellular | 4.6 | [109] | BANCR | Hepatocellular | NA | [143] | SNHG3 | Hepatocellular | NA | [144] | MVIH | Hepatocellular | 3.75 | [145] | | Lung | NA | [146] | LCAL1 | Lung | NA | [147] | LUADT1 | Lung | NA | [148] | AFAP1-AS1 | Lung | NA | [149] | | Colorectal | NA | [150] | | Hepatocellular | NA | [151] | | Esophageal | >1.0 | [152] | ANRIL | Lung | >1.5 | [153] | | Hepatocellular | >1.0 | [154] | | Bladder | >1.0 | [155] | UCA1 | Lung | NA | [156] | | Oral | NA | [157] | | Bladder | 32.9 | [158] | | Colon | NA | [159] | | Hepatocellular | NA | [160] | | Breast | NA | [161] | | Esophageal | >2.0 | [162] | CASC15 | Melanoma | NA | [163] | SPRY4-IT1 | Melanoma | >2.0 | [164, 165] | | Glioma | NA | [166] | H19 | Bladder | NA | [167] | | Gastric | NA | [83] | | Esophageal | NA | [168] | | Colorectal | NA | [169] | | Glioma | NA | [170] | HULC | Pancreas | NA | [171] | | Hepatocellular | 32.7 | [102] | | Glioma | NA | [172] | PCA3 | Prostate | NA | [34, 99] | PCAT5 | Prostate | NA | [173] | PCAT18 | Prostate | 8.8–11.1 | [174] | PRNCR1 | Prostate | NA | [175] | NEAT1 | Glioma | NA | [176, 177] | | Oral | NA | [74] | | Hepatocellular | NA | [178] | | Nasopharyngeal | NA | [179] | PVT1 | Thyroid | NA | [180] | | Gastric | NA | [181] | | Colorectal | NA | [182] | SRA | Breast | NA | [183] |
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aFold change values, relative to normal controls; bnot available (data is presented in a graphical format in the original report).
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