Long Noncoding RNAs as Biomarkers in Cancer

Table 1

Upregulated cancer-associated lncRNAs when compared to normal tissues.

Name	Cancer type	Fold change^a	References
Wt1-as	Acute myeloid leukemia	NA^b	[111]
XIST	Glioma	NA	[112]
CRNDE	Glioma	NA	[113]
MALAT1	Glioma	2.0–5.0	[114]
	Colorectal	2.0–6.0	[115]
	Lung	>40.0	[116]
	Prostate	NA	[84]
	Hepatocellular	NA	[117]
	Uterus	NA	[118]
LSINCT5	Breast	2.0–7.0	[119]
LINC00617	Breast	>1.5	[120]
RP11-445H22.4	Breast	15.0–20.0	[121]
BC200	Breast	NA	[122]
CCHE1	Cervical	NA	[123]
CCAT1-L	Colorectal	NA	[71]
POU3F3	Esophageal	NA	[124]
PCAT-1	Colorectal	NA	[125]
	Prostate	NA	[126]
HOTAIR	Esophageal	NA	[127]
	Lung	NA	[128]
	Cervical	NA	[129]
	Pancreas	NA	[130]
	Breast	NA	[52]
	Oral	NA	[131]
	Hepatocellular	>2.0	[132]
	Glioma	NA	[133, 134]
	Colorectal	5.2	[101]
CCAT2	Lung	7.5	[135]
	Colon	NA	[136]
	Cervical	NA	[137]
LINC00152	Gastric	NA	[35, 90]
LSINCT-5	Gastric	NA	[138]
HOXA11-AS	Glioma	NA	[139]
Linc-POU3F3	Glioma	>2.6	[140]
ATB	Glioma	5.0–10.0	[141]
AB073614	Glioma	NA	[142]
RP11-160H22.5	Hepatocellular	2.5	[109]
XLOC_014172	Hepatocellular	67.7	[109]
LOC149086	Hepatocellular	4.6	[109]
BANCR	Hepatocellular	NA	[143]
SNHG3	Hepatocellular	NA	[144]
MVIH	Hepatocellular	3.75	[145]
	Lung	NA	[146]
LCAL1	Lung	NA	[147]
LUADT1	Lung	NA	[148]
AFAP1-AS1	Lung	NA	[149]
	Colorectal	NA	[150]
	Hepatocellular	NA	[151]
	Esophageal	>1.0	[152]
ANRIL	Lung	>1.5	[153]
	Hepatocellular	>1.0	[154]
	Bladder	>1.0	[155]
UCA1	Lung	NA	[156]
	Oral	NA	[157]
	Bladder	32.9	[158]
	Colon	NA	[159]
	Hepatocellular	NA	[160]
	Breast	NA	[161]
	Esophageal	>2.0	[162]
CASC15	Melanoma	NA	[163]
SPRY4-IT1	Melanoma	>2.0	[164, 165]
	Glioma	NA	[166]
H19	Bladder	NA	[167]
	Gastric	NA	[83]
	Esophageal	NA	[168]
	Colorectal	NA	[169]
	Glioma	NA	[170]
HULC	Pancreas	NA	[171]
	Hepatocellular	32.7	[102]
	Glioma	NA	[172]
PCA3	Prostate	NA	[34, 99]
PCAT5	Prostate	NA	[173]
PCAT18	Prostate	8.8–11.1	[174]
PRNCR1	Prostate	NA	[175]
NEAT1	Glioma	NA	[176, 177]
	Oral	NA	[74]
	Hepatocellular	NA	[178]
	Nasopharyngeal	NA	[179]
PVT1	Thyroid	NA	[180]
	Gastric	NA	[181]
	Colorectal	NA	[182]
SRA	Breast	NA	[183]

^aFold change values, relative to normal controls; ^bnot available (data is presented in a graphical format in the original report).