A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules

Table 3

Salivary biomarkers in periodontitis.

Salivary biomarker	Function	References
IL-1	Strong relation with periodontal disease; high inflammatory potential	[25, 28–33, 45]
IL-6	Stimulates osteoclastic differentiation; increased levels in periodontal disease; regulated the immune responses	[34–38, 45]
Tumor necrosis factor	Influences the bone collagen synthesis	[28, 39, 45]
Matrix metalloproteinase-9	Mediator of the immune response and tissue destruction in periodontal disease	[40–43]