The Effects of Baclofen for the Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of the baclofen studies included in this meta-analysis.

Source	Study design	Parameters evaluated	Number of patients	Mean age	Study duration	Dosing regimen
Beaumont and Boeckxstaens (2009) [12]	DB, RCT crossover	Incidence of GER,; acid reflux time	27	54.0	12 d	T.i.d 20 mg
Cange et al. (2002) [13]	DB, RCT crossover	Incidence of acid GER,; acid reflux time	20	41.2	4 w	Q.d 40 mg
Ciccaglione and Marzio (2003) [14]	DB, RCT	Incidence of GER,; acid reflux time	43	41.0	4 w	Q.i.d 10 mg
	DB, RCT	Incidence of GER,; acid reflux time	43	49.0	2 w	T.i.d
						10, 10, 10 mg (D1–3)
Cossentino et al. (2012) [15]						20, 10, 10 mg (D4)
						20, 20, 10 mg (D5)
						20, 20, 20 mg (D6–14)
Gerson et al. (2010) [16]	DB, RCT crossover	Incidence of GER, heartburn	50	41.0	4 w	Q.d, 4 different doses
						10, 20, 40, 60 mg
Grossi et al. (2008) [17]	DB, RCT	Incidence of TLESR	23	43.0	2 d	Q.i.d 10 mg
Lidums et al. (2000) [18]	DB, RCT	Incidence of GER,; incidence of TLESR,; acid reflux time, and; rate of swallowing	20	24.0	1 w	Q.2d 40 mg
Omari et al. (2006) [19]	DB, RCT^1	Incidence of TLESR,; incidence of GER,; gastric emptying,; pharyngeal swallow,; LES pressure, and; acid reflux time	30	10.0	12 h	A single dose 0.5 mg/kg
van Herwaarden et al. (2002) [20]	DB, RCT crossover	Incidence of TLESR,; incidence of GER, and; acid reflux time	37	42.3	4 days	Q.d 40 mg

DB: double-blinded; GER: gastroesophageal reflux; RCT: randomized controlled trial; Q.d: once per day; T.i.d: 3 times per day; Q.i.d: 4 times per day; Q.2d: once per 2 days.