Review Article
Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models
Figure 6
Compound 35 in the ATP binding pocket of GSK-3β; important protein-inhibitor interactions are shown. The distance is denoted by Å. PDB code 3M1S [62].
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(a) Compound 35 in the ATP binding pocket of GSK-3β |
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(b) Rotated (a) to reveal the hydrophobic pocket containing Ile62, Phe67, Gly83, Val70, Lys85, and Glu97 |
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