Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

Table 1

Examples of maleimide inhibitors with biological activity against GSK-3, selectivity, X-ray and reference.

No.	R^1	R^2	IC50 (nM)	Kinase panel	In vivo	X-ray	Year/lit.
1			α: 20	—	—	—	2001 [30]
2			α: 26	𝛽+24	—	—	2001 [30]
3			α: 76	—	—	1Q4L	2001, 2003 [30, 31]

α: GSK-3α; β: GSK-3β.