Tissue-Based MRI Intensity Standardization: Application to Multicentric Datasets

<table>Standardized images for Subject 1 in the Pilot E-ADNI dataset. From top to bottom: linearly registered input images, standard image, and images standardized with <svg height="15.25" id="M25" style="vertical-align:-3.276pt" version="1.1" viewbox="0 0 16.1625 15.25" width="16.1625" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,0,0,-.017,.062,11.113)"><path d="M559 163q-23 -66 -68 -163h-474l6 26q62 4 79.5 19.5t28.5 75.5l78 409q7 35 8.5 49t-8 25t-24 13t-51.5 5l5 28h266l-6 -28q-65 -5 -79.5 -18t-25.5 -74l-76 -406q-10 -57 14 -75q12 -13 96 -13q93 0 126 29q41 40 76 109z" id="x1D43F"></path></g>
<g transform="matrix(.012,0,0,-.012,9.763,15.188)"><path d="M456 178h-96v-72q0 -51 12.5 -62.5t72.5 -16.5v-27h-256v27q65 5 78 17t13 62v72h-260v28q182 271 300 426h40v-407h96v-47zM280 225v295h-2q-107 -148 -196 -295h198z" id="x34"></path></g>
</svg> and STI, respectively. From left to right: images for Sites 1 to 7. Color coding enhances intensity differences.</table>

International Journal of Biomedical Imaging

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Figure 2

Figure 2: Tissue-Based MRI Intensity Standardization: Application to Multicentric Datasets 