Liposomal Systems as Nanocarriers for the Antiviral Agent Ivermectin

Figure 7

In vitro cytotoxicity effect of ivermectin formulated in liposomes (closed circles) on Vero-F cells. For comparison the same experiments were performed using empty liposomal formulations (open circles). The following liposomal formulations were tested: #PC9-Ch1 and #PC9-Ch1-ive1.0 (a), #PC9-Br1 and #PC9-Br1-ive1.0 (b), #PC9-Br0.5 and #PC9-Br0.5-ive1.0 (c), and #PC18-Br1 and #PC18-Br1-ive1.0 (d). The phosphatidylcholine concentration (top -axis) is related to empty liposomes while the ivermectin concentration (bottom -axis) is related to ivermectin liposomes. Details on the identification codes and liposomal compositions are included in Table 1. Data represent the average of 2 determinations.

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