How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin

Table 2

Effects of myo-inositol supplementation therapy (adding in oocytes culture or orally administered to patients) during ART.

Authors	Species	Myo-inositol; in vitro/in vivo	Patients number (tot)	Intervention/control; number	Technique	Significant outcomes; ()
Pesty et al. 1994 [67]	Mouse	Adding MI in oocyte culture medium				(i) Improved oocyte maturation
Chiu et al. 2002 [48]	Human	Adding MI in oocyte culture medium	53	32/21	IVF	(i) Improved good quality oocyte; (ii) Increased FF volume
Brusco and Mariani 2013 [68]	Human	Orally administered MI + FA (2 g + 400 mg/day) versus FA (400 mg/day)	149	58/91	IVF-ET; ICSI	(i) Improved number of good quality oocytes; (ii) Improved number embryos of grade A; (iii) Increased clinical pregnancy rate
Ciotta et al. 2011 [69]	Human	Orally administered MI + FA (2 g + 200 mg/twice daily) versus FA (400 mg/day)	34	17/17	IVF-ET; ICSI	(i) Increased number oocytes retrieved; (ii) Increased numbers embryos transfer; (iii) Increased grade S1 embryos; (iv) Reduced number of immature oocytes
Unfer et al. 2011 [71]	Human	Orally administered MI (2 g/twice daily) versus DCI (0.6 g/twice daily)	84	43/41	IVF-ET; ICSI	(i) Increased numbers mature oocyte; (ii) Reduced number of immature oocytes; (iii) Increased embryos grade 1
Colazingari et al. 2013 [72]	Human	Orally administered MI + DCI (1.1 g + 27.6 mg/day) versus DCI (0.5 g/day)	100	46/53	IVF-ET	(i) Improved oocyte quality; (ii) Improved embryos quality; (iii) Improved pregnancies rate
Papaleo et al. 2009 [70]	Human	Orally administered MI + FA (2 g + 200 mg/twice daily) versus FA (400 mg/day)	60	30/30	IVF-ET; ICSI	(i) Reduced number of immature oocytes; (ii) Decreased FSH unit and day of stimulation; (iii) Decreased E2 level before hCG stimulation

MI: myo-inositol; FA: folic acid; E2: estradiol; DCI: D-chiro-inositol; FF: follicular fluid; IVF: in vitro fertilization; ET: embryo transfer; ICSI: intracytoplasmic sperm injection; FSH: follicle stimulating hormone; hCG: human chorionic gonadotropin.