International Journal of Endocrinology / 2016 / Article / Tab 2 / Review Article
How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin Table 2 Effects of myo-inositol supplementation therapy (adding in oocytes culture or orally administered to patients) during ART.
Authors Species Myo-inositol in vitro/in vivo Patients number (tot) Intervention/control number Technique Significant outcomes ( ) Pesty et al. 1994 [67 ] Mouse Adding MI in oocyte culture medium (i) Improved oocyte maturation Chiu et al. 2002 [48 ] Human Adding MI in oocyte culture medium 53 32/21 IVF (i) Improved good quality oocyte (ii) Increased FF volume Brusco and Mariani 2013 [68 ] Human Orally administered MI + FA (2 g + 400 mg/day) versus FA (400 mg/day) 149 58/91 IVF-ET ICSI (i) Improved number of good quality oocytes (ii) Improved number embryos of grade A (iii) Increased clinical pregnancy rate Ciotta et al. 2011 [69 ] Human Orally administered MI + FA (2 g + 200 mg/twice daily) versus FA (400 mg/day) 34 17/17 IVF-ET ICSI (i) Increased number oocytes retrieved (ii) Increased numbers embryos transfer (iii) Increased grade S1 embryos (iv) Reduced number of immature oocytes Unfer et al. 2011 [71 ] Human Orally administered MI (2 g/twice daily) versus DCI (0.6 g/twice daily) 84 43/41 IVF-ET ICSI (i) Increased numbers mature oocyte (ii) Reduced number of immature oocytes (iii) Increased embryos grade 1 Colazingari et al. 2013 [72 ] Human Orally administered MI + DCI (1.1 g + 27.6 mg/day) versus DCI (0.5 g/day) 100 46/53 IVF-ET (i) Improved oocyte quality (ii) Improved embryos quality (iii) Improved pregnancies rate Papaleo et al. 2009 [70 ] Human Orally administered MI + FA (2 g + 200 mg/twice daily) versus FA (400 mg/day) 60 30/30 IVF-ET ICSI (i) Reduced number of immature oocytes (ii) Decreased FSH unit and day of stimulation (iii) Decreased E2 level before hCG stimulation
MI: myo-inositol; FA: folic acid; E2: estradiol; DCI: D-chiro-inositol; FF: follicular fluid; IVF: in vitro fertilization; ET: embryo transfer; ICSI: intracytoplasmic sperm injection; FSH: follicle stimulating hormone; hCG: human chorionic gonadotropin.