Review Article

Magnesium and Human Health: Perspectives and Research Directions

Table 1

Role of vitamins and hormones in magnesium homeostasis.

Hormone/vitaminRole of hormones/vitaminsComments

Vitamin D1,25-Dihydroxyvitamin D3 can stimulate intestinal magnesium absorption.Mg is required for metabolism of vitamin D in the liver and the kidneys and also for its transportation in serum.
PTHHelps in the reabsorption of Mg in the kidney, absorption in the gut, and release from the bone.Hypercalcemia interferes with the role of PTH in magnesium regulation.
EstrogenEnhances Mg reabsorption in the kidney and absorption in the gut by stimulating TRPM6 expression.ā€‰

Mg: magnesium; PTH: parathyroid hormone.