The Effect of Citalopram on Genome-Wide DNA Methylation of Human Cells

Figure 1

Heat map of hypermethylated and hypomethylated gene promoters. This heat map represents differentially methylated gene promoters between citalopram-treated (B1, B2, and B3) and control (C1, C2, and C3) samples with significant values from MeDIP chip analysis, grouped into clusters. The scale represents hypermethylated gene promoters (values 0 to +2) in blue and hypomethylated gene promoters (values 0 to −2) in red. Each column represents a gene, as specified on the gene axis at the bottom, that is either downregulated (hypermethylated promoters in blue) or upregulated (hypomethylated promoters in red) between samples represented in the six rows. The right axis represents overall methylation clustering between treated and control samples, and the top axis represents quantitative methylation clustering between significant genes.