The Effect of Citalopram on Genome-Wide DNA Methylation of Human Cells

Figure 2

Venn diagram of genes involved in depression with significant differential methylation. This figure shows a set of 13 genes identified from our dataset with significant differential methylation resulting from citalopram treatment overlapping with a curated list of genes implicated in psychological depression according to the current IPA database, shown in Venn diagram form. Genes are classified according to their subcellular location, value, and expression value where positive expression values indicate upregulation and negative expression values represent downregulation. A few important genes included in this list are OXT, GRIN1, CHAT, and CACNA1D which are potential regulators of neurophysiological processes and have a high degree of implication in psychological disorders.