Goat Genomic Resources: The Search for Genes Associated with Its Economic Traits

Table 5

Genes related to adaptation in goat.

Gene name	Chromosome	Exon	Function	Founder breeds/population	References
CDK2	5	8	Involved in hypoxic adaptation	Tibetan cashmere goat	[18, 89–93]
SOCS2	5	6
NOXA1	11	14
ENPEP	6	20
EPAS1	11	16	Associated with high-altitude adaptation		[13, 97, 102]
IFNGR2	1	10
MAPK4	24	6
NOX4	29	18
SLC2A4	19	11
PDK1	2	11
IDE	26	26
IGF1	5	7
P2RX3	15	12
PHF6	X	11
PROX1	16	7
RYR1	18	106
ADCY4	10	26	Involved in the regulation of the insulin secretion, adrenergic signalling in the various pathways	Inner Mongolia and Liaoning cashmere goat	[100, 101]
ROCK1	24	33	Involved in the oxytocin signalling pathway which functionally related to the regulation of skin development, fat metabolism, and ion homeostasis		[99]
ACNA1C	5	50
OXTR	22	5
SLC24A4	21	17	Plays a central role in hypoxia-related cellular responses
CACNA2D1	4	40	Involved in the renin secretion pathway and may also play essential roles in hypoxia-mediated cellular responses
AGT	28	5
PTGER2	10	2