Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

Figure 12

Deep brain imaging. The system is able to image vasculature up to 900 μm deep in the brain of a rat. When imaging deep regions of a brain, the large pial vessels on the surface block the OCT beam and create dark and noisy areas in the OCT angiography images. (a) and (b) are obtained from the same region but at different depths. The shadow of the superficial vessels on (a) prevents imaging the capillaries at deeper regions that are shown on (b). The scale bars are 200 μm.