Main disease-related autoantibody specificities in autoimmune pancreatitis. Several autoantibodies have been detected in the sera of patients with autoimmune pancreatitis (AIP). Although none have been established to be disease specific, it appears that a loss of tolerance to several pancreatic antigens may be involved in the initiation of AIP. The prevalence of antibodies against carbonic anhydrase, lactoferrin, heat-shock protein 10, amylase alpha, plasminogen-binding protein, and pancreatic secretory trypsin inhibitor antigens, key references of studies investigating autoantibodies against these antigens as well as the origin of the cohorts are provided. Information regarding conventional autoantibodies, such as, antinuclear and smooth muscle autoantibodies is provided within the text.