Development of an HPLC-UV Method for the Analysis of Drugs Used for Combined Hypertension Therapy in Pharmaceutical Preparations and Human Plasma

Table 3

Precision and accuracy of intraday and interday analyses at the low (1 µg/mL for all substances), medium (10 µg/mL for all substances), and high (15 µg/mL for AML and VAL, 20 µg/mL for OLM and HCT) concentration levels.

	Low (𝜇g/mL)		Medium (𝜇g/mL)		High (𝜇g/mL)
	Intraday	Interday	Interday	Intraday	Interday	Intraday
RSD%
AML	5.2	6.1	4.8	6.0	4.2	5.4
OLM	5.4	5.7	3.9	4.3	3.5	4.1
VAL	6.5	6.9	6.3	6.5	5.8	6.3
HCT	4.2	4.6	4.1	4.5	3.6	4.3
RME%
AML	9.3	10.6	9.1	9.6	7.4	8.2
OLM	4.5	5.2	4.7	5.8	3.3	5.4
VAL	6.5	5.4	6.2	4.3	5.7	3.9
HCT	5.6	6.7	5.5	5.9	6.5	6.8