Cancer Incidence and Mortality in a Cohort of US Blood Donors: A 20-Year Study

Table 2

Standardized incidence ratio (SIR) for all cancers, allogeneic blood donors with more than one year of followup, Blood Centers of the Pacific, 1991–2009 (𝑛 = 54,982).

Age group	Number of donors	Person-years	Observed	Expected	SIR	95% CI
Males
18–29	6,382	97,018.3	95	40.9	2.32	1.88	2.84
30–39	8,077	122,190.7	223	105.7	2.11	1.84	2.41
40–49	7,497	111,655.3	575	236.7	2.43	2.23	2.64
50–59	3,992	55,664.0	737	404.7	1.82	1.69	1.96
60–69	1,794	22,632.8	528	436.3	1.21	1.11	1.32
70+	349	3,928	102	121.2	0.84	0.69	1.02
Males total	28,091	413,088.8	2,260	1,345.5	1.68	1.61	1.75
Females
18–29	7,546	112,935.3	160	57.4	2.79	2.37	3.26
30–39	7,894	118,319.1	346	162.3	2.13	1.91	2.37
40–49	6,609	97,661.8	561	336.5	1.67	1.53	1.81
50–59	3,275	45,759.0	444	314.5	1.41	1.28	1.55
60–69	1,356	18,481.9	275	226.5	1.21	1.07	1.37
70+	211	2,609	46	46.0	1.00	0.73	1.33
Females total	26,891	395,766.1	1,832	1,143.2	1.60	1.53	1.68
Total	54,982	808,854.9	4,092	2,488.7	1.64	1.59	1.70

Person-years of followup: from date of first repository donation to cancer diagnosis, death or Dec. 31, 2009.
SIR: observed/expected.
Expected: SEER age-adjusted and sex- and age-specific incidence rate × person-years of followup.
Age-adjusted incidence rates: SEER age-adjusted rates for malignant cases, years of diagnosis 1992–2009.
Standard population: US 2000 population.