Epididymal AT death peaks at 16 weeks of HFD, compared to 12 and 20 weeks. This is coincident with a peak of AT macrophages. Inguinal AT death was less pronounced at all times tested.
At 8 months hyperglycemia, hyperinsulinemia, and hypercholesterolemia and insulin resistance were found. Cardiac remodeling by echo was also identified. At 16 months the authors also report cardiac metabolic compensations and tissue remodeling in the form of fibrosis and hypertrophy.