Brain Tumours: Rise in Glioblastoma Multiforme Incidence in England 1995–2015 Suggests an Adverse Environmental or Lifestyle Factor

Table 4

Age standardised incidence rates to ESP-2013 (/100k people).

Year	GBM all brain sites				all ages	all ages	GBM frontal and temporal lobes				all ages	all ages
age>	< 30	30-54	55+	all ages	M	F	< 30	30-54	55+	all ages	M	F
AAPC	2.6	1.7	4.1	3.6	3.5	3.7	5.6	4.7	7.6	6.9	6.8	6.9
CI	1.5 3.9	1.2 2.2	3.5 4.7	3.1 4.1	2.9 4.1	3.2 4.1	4.0 7.3	3.9 5.5	7.0 8.2	6.3 7.4	6.2 7.4	6.4 7.5
p	0.0002	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
1995	0.13	1.87	5.33	2.39	2.99	1.85	0.03	0.64	1.64	0.76	0.90	0.62
1996	0.16	1.95	5.77	2.57	3.22	1.98	0.04	0.66	1.64	0.76	0.98	0.57
1997	0.19	1.87	7.1	2.98	3.87	2.21	0.06	0.66	2.08	0.91	1.17	0.68
1998	0.22	2.08	6.73	2.95	3.74	2.23	0.06	0.78	2.16	0.98	1.31	0.67
1999	0.20	2.34	7.51	3.28	4.28	2.35	0.06	0.99	2.34	1.11	1.42	0.82
2000	0.24	2.34	7.87	3.41	4.39	2.52	0.08	0.94	2.45	1.14	1.50	0.81
2001	0.25	2.14	8.04	3.39	4.30	2.58	0.11	0.89	2.59	1.17	1.50	0.89
2002	0.15	2.39	8.73	3.67	4.76	2.72	0.06	1.03	3.29	1.43	1.92	0.99
2003	0.24	2.22	8.95	3.71	4.84	2.69	0.07	0.89	3.23	1.37	1.81	0.97
2004	0.19	2.33	9.35	3.86	5.00	2.87	0.07	1.06	3.25	1.43	1.82	1.07
2005	0.23	2.55	9.74	4.07	5.39	2.88	0.09	0.94	3.66	1.53	2.00	1.1
2006	0.25	2.41	10.25	4.19	5.35	3.16	0.10	1.06	3.95	1.66	2.13	1.22
2007	0.26	2.51	10.88	4.43	5.68	3.34	0.09	1.07	4.50	1.84	2.35	1.38
2008	0.25	2.82	11.41	4.71	5.91	3.63	0.12	1.51	5.05	2.18	2.73	1.66
2009	0.24	2.66	11.39	4.64	5.88	3.53	0.08	1.39	5.30	2.20	2.79	1.66
2010	0.23	2.52	11.14	4.51	5.75	3.41	0.10	1.39	5.15	2.16	2.82	1.55
2011	0.26	2.62	12.1	4.86	6.04	3.82	0.11	1.56	5.76	2.42	3.05	1.84
2012	0.27	2.57	12.07	4.84	6.22	3.61	0.10	1.49	5.71	2.37	3.10	1.72
2013	0.30	2.60	12.97	5.15	6.64	3.80	0.11	1.49	6.59	2.66	3.47	1.91
2014	0.22	2.44	11.93	4.73	6.02	3.59	0.14	1.45	6.43	2.60	3.27	2
2015	0.32	2.83	12.28	5.02	6.26	3.91	0.15	1.65	6.60	2.73	3.33	2.18