Peptide-Based Treatment: A Promising Cancer Therapy

Table 3

Peptide-based vaccine in clinical application.

Cancer	Treatment	Sample	Study phase	Year	Author	Reference
Pancreatic cancer	WT1 peptide-based vaccine combined with gemcitabine	32	I	2014	Nishida et al.	[27]
	KIF20A-derived peptide in combination with gemcitabine	9	I	2014	Suzuki et al.	[28]
	Telomerase GV1001 vaccine together with gemcitabine	21	I	2014	Staff et al.	[29]
Gastric cancer	VEGFR1-1084 and VEGFR2-169 combined with S-1 and cisplatin	22	I/II	2012	Masuzawa et al.	[30]
	LY6K-177 peptide vaccine emulsified with Montanide ISA 51	6	I	2014	Ishikawa et al.	[31]
Prostate cancer	PPV (2-4 positive peptides selected from 31 candidate peptides)	100	II	2013	Noguchi et al.	[47]
	IB-PAP-114-128 vaccine therapy	—	—	2014	Saif et al.	[32]
	A multipeptide, dual-adjuvant telomerase vaccine (GX301)	11	I/II	2013	Fenoglio et al.	[48]
mrTNBC	PPV	18	II	2014	Takahashi et al.	[9]
Breast cancer	P5 encapsulated in DOTAP-cholesterol-DOPE liposomes coadministered with CpG-ODN	—	—	2014	Mansourian et al.	[33]
	Optimized encapsulation of p5 into liposomes	—	—	2014	Shariat et al.	[49]
	An artificial long peptide consisting of SU18 and SU22	—	—	2014	Ohtake et al.	[34]
	Combination therapy of E75 and GM-CSF	187	I/II	2014	Mittendorf et al.	[35]
	Multiepitope derived from ErbB-2 vaccine	—	—	2014	Gil et al.	[36]
Colorectal cancer	Atrial natriuretic peptide (ANP)	—	—	2012	Serafino et al.	[37]
	TCP-1 peptide	—	—	2010	Li et al.	[38]
	F56-VCR-NP	—	—	2014	Wang et al.	[39]
	Peptides from common bean NDF	—	—	2014	Luna Vital et al.	[50]
	Cep55/c10orf3 derived peptide vaccine	—	—	2011	Inoda et al.	[51]
	A cocktail vaccine of 5 peptides	18	I	2014	Hazama et al.	[52]
	A combination of 7-peptide cocktail vaccine and tegafur-uracil plus leucovorin	30	I	2014	Okuno et al.	[53]
Lung cancer	Dendritic cell vaccines pulsed with WT-1 peptide	62	—	2013	Takahashi et al.	[40]
	hTERT-targeting Vx-001 vaccine	46	II	2014	Kotsakis et al.	[41]
	A synthesized peptide Disruptin	—	—	2014	Ahsa et al.	[42]
	A ligand-independent peptide-based TREM1 inhibitor	—	—	2014	Sigalov	[43]
	Peptide fractions from high oleic acid soybean	—	—	2013	Rayaprolu et al.	[54]
	Peptides from venom of Eastern green mamba	—	—	2014	Conlon et al.	[55]
	LFC131-DOX NPs delivery system	—	—	2014	Chittasupho et al.	[44]
	TH10-DTX-NP	—	—	2014	Guan et al.	[46]
	BPP-decorated chitosan nanoparticles	—	—	2014	Wang et al.	[45]