Atypical Mucin Expression Predicts Worse Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma

Figure 2

Survival curves of PDAC patients in relevant to mucin expression. The survival plots were plotted by Kaplan-Meier’s method, and Mantel-Cox tests were used to compare the curves. (a–c) FUSCC cohort was stratified by mucins’ IHC staining results. (a) MUC1-negative patients () had worse survival compared to MUC1-positive patients (). (b) MUC2-positive patients () tended to survive a shorter time compared to MUC2-negative patients (). (c) There was no statistical significance of overall survival between the subgroups stratified by MUC5AC expression ( and , respectively). (d) The cut-off value of 77.90 TPM stratified the QCMG cohort into the high MUC1 expression subgroup () and the low MUC1 expression subgroup () with a significant difference in OS. (e) The cut-off value of 0.682 TPM stratified the QCMG cohort into the high MUC2 expression subgroup () and the low MUC2 expression subgroup () with a marginally significant difference in OS. (f) The cut-off value of 17.83 TPM stratified the QCMG cohort into the high MUC5AC expression subgroup () and the low MUC5AC expression subgroup (); although the survival curves had a separating tendency in the early stage, there was no statistical OS difference. Abbreviations: PDAC: pancreatic ductal adenocarcinoma.

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