The Predictors of Target Lesion Revascularization and Rate of In-Stent Restenosis in the Second-Generation Drug-Eluting Stent Era

Table 5

Lesion characteristics and DS% progression rate according to types of DESs.

Clinical Factors	Overall	CoCr-EES	ZES	BES	PtCr-EES	P
	(N=944)	(N=244)	(N=310)	(N=166)	(N=224)
Reference vessel diameter (mm)	2.92±0.52	2.97±0.56	2.91±0.52	2.96±0.49	2.85±0.48	0.054
Lesion length (mm)	27.73±17.25	26.04±16.45	28.97±17.98	26.56±15.96	28.93±18.05	0.247
Pre-procedure MLD (mm)	0.73±0.50	0.76±0.53	0.65±0.51	0.87±0.44	0.71±0.46	0.755
MLD in-segment (mm)
(i) Post-procedure	2.11±0.52	2.13±0.55	2.08±0.52	2.13±0.50	2.11±0.51	0.906
(ii) follow-up	1.97±0.58	1.97±0.59	1.99±0.57	1.95±0.58	1.96±0.58	0.726
(iii) follow-up	1.96±0.52	2.01±0.55	1.94±0.52	1.96±0.49	1.93±0.52	0.180
MLD in-stent (mm)
(i) Post-procedure	2.48±0.44	2.49±0.47	2.47±0.43	2.47±0.42	2.48±0.44	0.852
(ii) follow-up	2.19±0.60	2.19±0.62	2.20±0.59	2.21±0.59	2.15±0.60	0.782
(iii) follow-up	2.13±0.55	2.16±0.61	2.12±0.54	2.17±0.50	2.09±0.54	0.480
Pre-procedure DS (%)	74.8±15.7	74.4±16.0	77.0±16.6	70.6±13.7	75.1±14.9	0.431
DS% in-segment
(i) Post-procedure	21.5±11.6	22.9±12.5	21.1±11.8	21.4±10.8	20.8±11.0	0.075
(ii) follow-up	26.2±16.5	27.3±17.0	25.0±15.9	27.5±17.6	25.8±15.9	0.649
(iii) follow-up	27.3±15.0	27.9±15.8	26.2±15.3	27.7±12.6	28.1±15.2	0.624
DS% in-stent
(i) Post-procedure	11.8±8.5	13.0±8.4	10.5±8.8	12.6±9.0	11.7±7.4	0.460
(ii) follow-up	22.0±17.5	22.4±17.9	20.8±16.4	21.8±18.3	23.3±17.9	0.454
(iii) follow-up	23.7±15.5	24.0±17.8	22.8±15.3	22.9±12.3	25.3±15.5	0.346
Acute gain (mm)
(i) In-segment	1.38±0.59	1.37±0.58	1.42±0.63	1.26±0.48	1.40±0.60	0.731
(ii) In-stent	1.74±0.54	1.73±0.53	1.81±0.58	1.61±0.47	1.75±0.51	0.395
Initial ΔDS	4.85±15.13	4.71±16.53	4.00±14.80	6.33±14.32	5.10±14.59	0.457
In-segment (%)
Initial ΔDS	10.28±15.89	9.52±16.02	10.27±15.15	9.46±14.43	11.72±17.63	0.204
In-stent (%)
Delayed ΔDS	3.66±11.87	3.65±13.52	2.82±11.53	4.04±9.95	4.55±11.81	0.264
In-segment (%)
Delayed ΔDS	4.59±11.60	4.81±14.08	3.73±9.87	5.27±11.49	5.10±11.11	0.486
In-stent (%)
Initial DS%/year in-segment	6.08±20.77	6.48±22.87	4.75±17.49	10.22 ±29.61	4.45±13.00	0.841
Initial DS%/year in-stent	12.12±20.97	12.23±20.92	12.15±18.60	14.34±29.76	10.36±15.74	0.525
Delayed DS%/year in-segment	2.98±9.84	2.65±9.93	2.09±9.57	3.26±7.89	4.30±11.16	0.130
Delayed DS%/year in-stent	3.68±10.10	4.11±12.83	2.39±8.13	4.02±8.30	4.77±10.46	0.205

CoCr-EES, cobalt chromium everolimus-eluting stent; ZES, zotarolimus-eluting stent; BES, Biolimus-eluting stent: PtCr-EES, platinum chromium everolimus-eluting stent; MLD, minimal lumen diameter; DS, diameter stenosis.