TAVR: A Review of Current Practices and Considerations in Low-Risk Patients
Table 4
Comparison of outcomes between TAVR and SAVR patients in Low-Risk TAVR Trials.
PARTNER III
Evolut Low-Risk
NOTION
All-cause and CV-mortality at 1 year
TAVR: 1.0 %
TAVR: 2.4%
TAVR: 4.9%
SAVR: 2.5%
SAVR: 3.0%
SAVR: 7.5%
Disabling stroke at 1 year
TAVR: 0.2%
TAVR: 0.8%
SAVR: 0.9%
SAVR: 2.4%
TAVR: 2.9%
Nondisabling stroke at 1 year
TAVR: 1.0%
TAVR: 3.4%
SAVR: 4.6%
SAVR: 2.2%
SAVR: 2.2%
TIA at 1 year
TAVR: 1.0%
TAVR: 1.7%
TAVR: 2.1%
SAVR: 1.1%
SAVR: 1.8%
SAVR: 1.6%
Major vascular complications at 30 days
TAVR: 2.2%
TAVR: 3.8%
TAVR: 5.6%
SAVR: 1.5%
SAVR: 3.2%
SAVR: 1.5%
AKI (stage II or III) (in 30 days)
TAVR: 0.4%
TAVR: 0.9%
TAVR: 0.7%
SAVR: 1.8%
SAVR: 2.8%
SAVR: 6.7%
New-onset AF (at 1 year)
TAVR: 7.0%
TAVR: 9.8%
TAVR: 21.2%
SAVR: 40.9%
SAVR: 38.3%
SAVR: 59.4%
New PPM implantation at 1 year
TAVR: 7.5%
TAVR: 19.4%
TAVR: 38.0%
SAVR: 5.5%
SAVR: 6.7%
SAVR: 2.4%
Coronary artery obstruction requiring intervention at 1 year
TAVR: 0.2%
TAVR: 0.9%
No TAVR-treated patient required PCI during the procedure; 1 SAVR patient required concomitant coronary artery bypass resulting from a right coronary ostium lesion
SAVR: 0.7%
SAVR: 0.4%
MI at 1 year
TAVR: 1.2%
TAVR: 1.7%
TAVR: 3.5%
SAVR: 2.2%
SAVR: 1.6%
SAVR: 6.0%
Valve thrombosis at 1 year
TAVR: 1.0%
TAVR: 0.2%
Not reported
SAVR: 0.2%
SAVR: 0.3%
PVL (≥moderate) at 1 year
TAVR: 0.6%
TAVR: 3.5%
TAVR: 15.7%
SAVR: 0.5%
SAVR: 0.5%
SAVR: 17.7%
Patient-prosthesis mismatch (30 days)
TAVR moderate: 29.8%
TAVR moderate: 5.0%
Not reported
SAVR moderate: 23.3%
SAVR moderate: 15.7%
TAVR severe: 4.3%
TAVR severe: 1.8%
SAVR severe: 6.3%
SAVR severe: 8.2%
Rehospitalization at 1 year (valve or procedure related, including CHF)
TAVR: 7.3%
TAVR: 3.2%
Not reported
SAVR: 11.0%
SAVR: 6.5% (CHF rehospitalization only)
AF = atrial fibrillation; AKI = acute kidney injury; CHF = congestive heart failure; CV = cardiovascular; MI = myocardial infarction; PCI = percutaneous coronary intervention; PPM = permanent pacemaker; PVL = paravalvular leak; TIA = transient ischemic attack. Although NOTION studied patients of all surgical risks; 81.8% of patients were considered low-risk (STS<4%).
