Use of Specific Chemical Reagents for Detection of Modified Nucleotides in RNA

<table>Depurination of wybutosine base (yW, Y-base) under mild acidic conditions. The formation of abasic site in RNA leads to the subsequent cleavage of the RNA chain.</table>

Journal of Nucleic Acids

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Figure 10

Figure 10: Use of Specific Chemical Reagents for Detection of Modified Nucleotides in RNA 