DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer

Figure 2

Lig4 depletion reduced cellular viability and colony forming ability. (a, b) Cell viability assessed using CellTiter Glo assay 72 hr after transfection with siRNA targeting Lig4 or scrambled control (NT; p<0.05). (c) BT549 cells depleted of Lig4 or scrambled control and subjected to clonogenic assay (p<0.01, n=3).

(a)

(b)

(c)