fibrinolyt enzym gene fibe wide conserv among bacillus spp belong group speci this encod serinelik enzym fibe secret extracellular medium this present work aim assess molecular use novel conserv housekeep gene among group bacillus spp identifi discrimin some relat strain tradit ferment food beverag republ congo first all 155 isol have been screen enzymat activ use caseinolyt assay pcr techniqu nest pcr method use specif primer correl 16s rna sequenc were use blot techniqu have been perform deep comparison molecular method result amyloliquefacien 1 licheniformi 1 subtili 1 pumilus 3 altitudini 2 atrophaeus 1 safensi 3 have been specif identifi among 155 isol found ferment food beverag genet analysi overexpress glutathion stransferas gsts fuse matur protein fibe escherichia coli bl21 top10 show 2fold higher enzymat activ comparison fibe wild type one immunodetect should associ doe clear discrimin bacillus belong group

Moïse Doria Kaya-Ongoto

Christian Aimé Kayath

Etienne Nguimbi

Aimé Augustin Lebonguy

Stech Anomène Eckzechel Nzaou

Paola Sandra Elenga Wilson

Gabriel Ahombo

Genetic Clearness Novel Strategy of Group I Bacillus Species Isolated from Fermented Food and Beverages by Using Fibrinolytic Enzyme Gene Encoding a Serine-Like Enzyme

gemcitabin 2 2 difluorodeoxycytidin dfdc deoxycytidin analog use primarili against pancreat cancer the cytotox gemcitabin due inhibit dna replic howev mechan remov incorpor dfdc larg unknown report discov nucleotid excis repair protein xpfercc1 particip repair gemcitabineinduc dna damag inactiv xpf sensit cell gemcitabin further analysi identifi xpfercc1 function togeth apurin apyrimidin endonucleas ape repair gemcitabineinduc dna damag our result demonstr import evalu dna repair activ gemcitabin treatment

Joseph W. George

Mika Bessho

Tadayoshi Bessho

Inactivation of XPF Sensitizes Cancer Cells to Gemcitabine

netrin form famili secret membraneassoci protein netrin involv process axon guidanc morphogenesi angiogenesi regul cell migrat surviv these process special interest tumor biolog from netrin gene various isoform translat regul altern splice review here divers isoform netrin famili member known potenti role cancer

Caroline Suzanne Bruikman

Huayu Zhang

Anneli Maite Kemper

Janine Maria van Gils

Netrin Family: Role for Protein Isoforms in Cancer

dna damag hallmark cancer mutat misregul protein maintain genom fidel associ develop multipl cancer dna doubl strand break arguabl consid most deleteri type dna damag the nonhomolog endjoin nhej pathway one mechan repair dna doubl strand break protein involv nhej may also regul dna replic previous establish dnapkcs nhej protein promot genom stabil cell viabil follow cellular exposur replic stress want discern whether anoth nhej protein dna ligas lig4 share phenotyp our investig focus tripl negat breast cancer cell compar nonbas breast cancer lig4 frequent amplifi increas gene dose associ higher lig4 express deplet lig4 use sirna confirm our knockdown qpcr western blot cell surviv diminish lig4 deplet alon associ increas replic fork stall checkpoint protein chk1 activ dephosphoryl were unchang lig4deplet cell lig4 deplet result sustain dnapkcs phosphoryl follow hydroxyurea exposur understand effect lig4 genom replic replic stress respons clarifi biolog ramif inhibit lig4 activ addit lig4 attract clinic target direct crispr cas9medi repair toward homologydirect repair away from nhej thus understand how diminish lig4 impact cell biolog critic

Rashmi R. Joshi

Sk Imran Ali

Amanda K. Ashley

DNA Ligase IV Prevents Replication Fork Stalling and Promotes Cellular Proliferation in Triple Negative Breast Cancer

About this journal

Journal of Nucleic Acids publishes original research articles as well as review articles covering all structural, chemical, and functional aspects of DNA and RNA research.

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Chief Editor, Professor Basu, is currently based at the University of Connecticut. His research focuses on determination of the consequences of DNA damaged by anti-tumor drugs, chemical carcinogens, oxidation, or radiation.

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Journal of Nucleic Acids