Gold Nanoparticle Mediated Phototherapy for Cancer

Figure 10

In vivo PDT and PTT. (a) Thermographic images captured after 1 min of light illumination and thermographic monitoring in the tumors of GNR-AlPcS4-injected and PBS-injected mice. (b) TUNEL staining of the tissue sections (magnification ×20). Normal or apoptotic cell nuclei are shown in green and brown, respectively. Empty areas in the tissue sections (GNR-AlPcS4 complex t PDT and GNR-AlPcS4 complex t PTT t PDT) are due to washout of the destroyed tumor cells during the staining procedure. (c) Tumor size after each therapy session. Points, mean; bars, standard deviation; PBS t PDT (); free AlPcS4 t PDT (); GNR-AlPcS4 complex t PDT (); GNR-AlPcS4 complex t PTT (); GNR-AlPcS4 complex t PTT t PDT (); = number of tumors involved. Reprinted with permission from [25]. Copyright American Chemical Society [25].

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