Review Article
Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2
Table 1
Biochemical and imaging screening for tumors in MEN 1 patients.
| Tumor | Annual biochemical tests | Imaging tests |
| Parathyroid | Calcium, PTH | — | GEP | Gastrin, glucagon, vasointestinal polypeptide, pancreatic polypeptide, chromogranin A, insulin, fasting glucose | MRI, CT, and endoscopic ultrasound (annually), gastroscopy with biopsy every 3 yr in patients with hypergastrinemia | Pituitary | PRL, IgF1 | MRI (every 3–5 yrs) | Adrenal | —1 | CT or MRI (every 3 yrs) | Thymus and lung | — | CT or MRI (every 1-2 yrs) |
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1Biochemical test should be performed in patients with tumors greater than 1 cm or with clinical features.
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