Genetic and Clinical Features of Multiple Endocrine Neoplasia Types 1 and 2

Table 1

Biochemical and imaging screening for tumors in MEN 1 patients.

Tumor	Annual biochemical tests	Imaging tests
Parathyroid	Calcium, PTH	—
GEP	Gastrin, glucagon, vasointestinal polypeptide, pancreatic polypeptide, chromogranin A, insulin, fasting glucose	MRI, CT, and endoscopic ultrasound (annually), gastroscopy with biopsy every 3 yr in patients with hypergastrinemia
Pituitary	PRL, IgF1	MRI (every 3–5 yrs)
Adrenal	—^1	CT or MRI (every 3 yrs)
Thymus and lung	—	CT or MRI (every 1-2 yrs)

¹Biochemical test should be performed in patients with tumors greater than 1 cm or with clinical features.