Review Article
To Treat or Not to Treat: The Role of Adjuvant Radioiodine Therapy in Thyroid Cancer Patients
Table 4
ATA risk of recurrence classification after initial surgery [
2].
| Low risk |
| (i) No local or distant mets | (ii) All macroscopic tumor has been resected | (iii) There is no tumor invasion of locoregional tissues or structures | (iv) Tumor does not have aggressive histology (e.g., tall cell, insular, columnar cell carcinoma) or vascular invasion | (v) If I-131 is given, there is no I-131 uptake outside the thyroid bed on the first posttreatment whole-body RAI scan |
| Intermediate risk |
| (i) Microscopic invasion of tumor into the perithyroidal soft tissue at initial surgery | (ii) Cervical LN mets or I-131 uptake outside the thyroid bed on the post-treatment whole-body RAI scan done after thyroid | remnant ablation | (iii) Tumor with aggressive history or vascular invasion |
| High risk |
| (i) Macroscopic tumor invasion | (ii) Incomplete tumor resection | (iii) Distant mets | (iv) Possibly thyroglobulinemia out of proportion to what is seen on the post-treatment scan |
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