Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells

<table>(a) combination effect of curcumin and garcinol on Panc-1 cell viability was determined using MTS assay. Combinatorial treatment significantly reduced cell viability more effectively than monotherapy on 48 hr treatment. *<svg height="11.25" id="M14" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
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</svg> relative to control. (b) isobologram analysis to evaluate the extent of synergism on combining curcumin and garcinol for therapeutic effect. Combination Index (CI) values at ED50 (effective dose at which 50% cells are nonviable) depicting the synergistic efficacy of garcinol and curcumin on PaCa cell line.</table>

Journal of Oncology

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Figure 5

Figure 5: Synergistic Effect of Garcinol and Curcumin on Antiproliferative and Apoptotic Activity in Pancreatic Cancer Cells 