Long-Term Survival, Quality of Life, and Psychosocial Outcomes in Advanced Melanoma Patients Treated with Immune Checkpoint Inhibitors

Figure 1

Overlay of Kaplan–Meier curves indicating the probability for overall survival (OS) for patients treated with ipilimumab as first line of immunotherapy, representing (1) the historical probability for OS for patients diagnosed with stage IV melanoma prior to the availability of life-prolonging medical treatment options (dashed black line) [1]; (2) a pooled OS analysis including individual patient survival data from 1,861 patients with metastatic melanoma from 12 clinical investigations of ipilimumab and 2,985 patients with metastatic melanoma from a US ipilimumab EAP (total n = 4,846) (dark blue line) [9]; (3) interim results from EURO-VOYAGE, a multicenter, observational, retrospective study of 1043 patients with advanced melanoma who participated in the EU ipilimumab EAP (purple line) [69]; (4) intention-to-treat population (365+362 patients) of the CA184-367 study comparing ipilimumab at 10 mg/kg (dark green line) to 3 mg/kg dosing level (light green line) [8]; (5) intention-to-treat population (278 patients) on the ipilimumab arm from the Keynote-006 trial (red line) [13]; (6) intention-to-treat population (315 patients) on the ipilimumab arm from the Checkmate-067 trial (pink line) [72].