The Effects of Noncompliance to Prolia (Denosumab) on the Changes in Bone Mineral Density: A Retrospective Review

Table 3

Regression analysis comparing change in bone mineral density (BMD) between groups [reference group: 5–7 months].

	Groups: time between 1st and 2nd injection was	Estimate	95% confidence limits
Lumbar spine	Greater than 7 months	0.00035	−0.0124 to 0.0131
	Less than 5 months	0.020	−0.0058 to 0.0479
Femoral neck	Greater than 7 months	−0.0054	−0.0171 to 0.0063
	Less than 5 months	0.0079	−0.0165 to 0.0324

All multivariable regression analyses were adjusted for baseline BMD values, age of the patient, proton pump inhibitors (yes/no), selective serotonin reuptake inhibitors (yes/no), serotonin-norepinephrine reuptake inhibitors (yes/no), tricyclic antidepressants (yes/no), and the number of months between the first and second BMD measurements.