Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study
Table 4
Blood levels of Mg, CRP, calcium, albumin, uric acid, cystatin C, IL-6, creatinine, and glomerular filtration rate (GFR) at gestational weeks 12 and 35 and change in levels (Δ) from week 12 to week 35 (PP).
Variable
Magnesium ( = 83)
Placebo ( = 93)
value
Mg 12
0.78 (0.06)/0.78
0.77 (0.04)/0.78 (0.68; 0.87)
0.30
Reference interval 0,71–0,94 mmol/L
(0.66; 0.92) = 82
= 90
Mg 35
0.75 (0.06)/0.76
0.73 (0.05)/0.73 (0.62; 0.86)
0.08
(0.63; 0.90) = 56
= 69
Δ Mg 12–35
-0.04 (0.05)/-0.05
-0.04 (0.06)/-0.04 (-0.21; 0.06)
0.72
(-0.16; 0.08) = 56
= 67
CRP 12
5.45 (4.80)/4.00
4.70 (3.88)/3.00 (2.00; 23.00)
0.26
(2.00; 26.00) = 82
= 90
CRP 35
5.98 (5.14)/4.00
5.38 (4.14)/4.00 (2.00; 25.00)
0.74
(2.00; 28.00) = 55
= 69
Δ CRP 12–35
0.62 (5.52)/0.00
0.82 (4.50)/0.00 (-21.00; 20.00)
0.27
(-11.00; 25.00) = 55
= 67
Calcium 12
2.32 (0.08)/2.31
2.31 (0.08)/2.31 (2.08; 2.58)
0.52
(2.12; 2.54) = 81
= 90
Calcium 35
2.29 (0.10)/2.30
2.28 (0.08)/2.27 (2.11; 2.46)
0.32
(2.08; 2.51) = 55
= 69
Δ calcium 12–35
-0.02 (0.11)/0.01
-0.03 (0.12)/-0.04 (-0.26; 0.25)
0.44
(-0.26; 0.24) = 54
= 68
Albumin 12
37.6 (2.7)/38.0 (30.0;
37.4 (2.5)/37.0 (31.0; 43.0)
0.42
44.0) = 80
= 89
Albumin 35
30.8 (2.2)/31.0 (25.0;
30.8 (2.3)/31.0 (26.0; 37.0)
0.73
36.0) = 55
= 69
Δ albumin 12-35
-7.00 (2.85)/-7.00
-6.69 (3.03)/-6.00 (-13.00; 2.00)
0.49
(-13.00; 1.00) = 54
= 67
Uric acid 12
199.6 (40.2)/200.0
198.4 (39.9)/
0.96
(103.0; 320.0) = 80
198.0 (99.0; 286.0) = 91
Uric acid 35
266.7 (66.8)/265.0
276.5 (63.0)/271.0 (153.0;
0.36
(140.0; 460.0) = 56
490.0) = 67
Δ Uric acid 12–35
70.7 (54.5)/71.0 (-34.0;
78.5 (49.8)/73.5 (-40.0; 232.0)
0.35
219.0) = 55
= 66
Cystatin C 12
0.596 (0.10)/0.59
0.580 (0.10)/0.56 (0.40; 0.89)
0.19
(0.36; 0.85) = 77
= 81
Cystatin C 35
0.99 (0.19)/0.97
1.05 (0.31)/1.02 (0.64; 2.61)
0.34
(0.62; 1.51) = 51
= 59
Δ C 12–35
0.41 (0.18)/0.40
0.47 (0.29)/0.42 (0.01; 1.74)
0.31
(0.16; 1.03) = 47
= 51
IL-6 12
6.72 (8.48)/3.60
7.76 (11.30)/4.65 (0.50; 96.00)
0.33
(0.70; 50.00) = 79
= 88
IL-6 35
11.7 (10.0)/8.3 (1.9; 55.0)
12.7 (10.6)/9.7 (2.9; 73.0)
0.32
= 51
= 67
Δ IL-6 12–35
5.97 (8.92)/4.05 (-7.00;
4.72 (14.67)/4.50 (-79.00;
0.80
36.10) = 48
52.00) = 63
Creatinine 12
50.8 (6.7)/51.0 (39.0; 76.0)
50.3 (8.0)/49.0 (34.0; 82.0)
0.58
= 82
= 91
Creatinine 35
50.6 (7.4)/52.0 (35.0; 69.0)
49.9 (9.1)/48.0 (36.0; 95.0)
0.33
= 56
= 69
Δ creatinine 12–35
-0.59 (6.77)/-1.000
-1.03 (6.55)/-1.00 (-15.00;
0.55
(-22.0;24.0) = 56
24.00) = 68
GFR 12
177.2 (46.7)/171.5
182.1 (43.7)/185.5
0.24
(101.0; 345.0) = 78
(94.0; 299.0) = 80
GFR 35
86.3 (21.7)/84.0
82.1 (24.8)/78.0 (20.0; 151.0)
0.26
(44.0; 138.0) = 52
= 59
Δ GFR 12–35
-95.6 (45.4)/-84.0
-97.9 (35.1)/-97.5 (-168.0; -
0.29
(-229.0; -27.0) = 49
15.0) = 50
For continuous variables, mean (SD)/median (min; max)/ is presented. For comparison between groups, the Mann–Whitney test was used for continuous variables.
