Review Article
Diet and Skin Cancer: The Potential Role of Dietary Antioxidants in Nonmelanoma Skin Cancer Prevention
Table 3
Serum AO levels and NMSC incidence.
| Study | Study design | Antioxidant supplements studied | Effect on NMSC risk | Statistically significant results | Study location |
| Clark et al., 1984 [42] | Case-control study of 240 subjects with NMSC | Selenium | Significantly lower levels in patients with NMSC | BCC: OR: 3.91; 95% CI: 1.2–13.1 | USA | | | | | | | Breslow et al., 1995 [67] | Nested case-control study of 30 BCC and 37 SCC patients using serum obtained prior to diagnosis of NMSC | Retinol Beta-carotene α-Tocopherol Selenium | None | NA | USA | | | | | | | Dorgan et al., 2004 [68] | Prospective cohort study of 302 subjects with history of BCC followed for 5 years | Carotenoids Vitamin E | None | NA | USA | | | | | | | | | Carotenoids | None | NA | | van der Pols et al., 2009 [69] | Prospective cohort study of 485 Australian adults followed for 8 years | Selenium | 60% decreased incidence high serum levels | BCC: RR: 0.43; 95% CI: 0.21–0.86; : 0.02 SCC: RR: 0.36; 85% CI: 0.15–0.82; : 0.02 | Australia | | | Vitamin E | None | NA | |
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BCC: basal cell carcinoma; CI: confidence interval; NA: not applicable; NMSC: nonmelanoma skin cancer; OR: odds ratio; : value; RR: relative rate; SCC: squamous cell carcinoma.
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