Research Article
Prevalence and Associations of Hypothyroidism in Indian Patients with Type 2 Diabetes Mellitus
(a) Comparison of clinical and biochemical parameters between clinical hypothyroid and euthyroid patients (continuous variables) |
| | Variable | Clinical hypothyroid
(n= 113) | Euthyroid
(n= 971) | P value | | Mean ± SD | Mean ± SD |
| | Body mass Index (kg/m2) | 28.20 ± 4.8 | 26.56 ± 3.9 | <0.001 | | Age (yrs) | 54.79 ± 9.9 | 53.14 ± 11.3 | 0.136 | | Duration of Diabetes (yrs) | 10.5 ± 7.8 | 9.50 ± 7.8 | 0.211 | | Height (cm) | 156.7 ± 8.5 | 162.64 ± 9.0 | <0.01 | | Weight (kg) | 68.85 ± 10.9 | 70.43 ± 12.3 | 0.14 | | Systolic BP (mm of Hg) | 131.07 ± 16.7 | 130.97 ± 18.1 | 0.95 | | Diastolic BP (mm of Hg) | 76.45 ± 8.2 | 77.24 ± 8.8 | 0.37 | | Waist Hip ratio | .98 ± 0.05 | .98 ± 0.1 | 0.76 | | Hemoglobin (%) | 12.2 ± 1.7 | 13.40 ± 1.6 | <0.001 | | Total Leucocyte count | 6570.54 ± 1648.4 | 6760 ± 2377.4 | 0.41 | | ESR (mm/hr) | 23.41 ± 19.0 | 17.87 ± 16.4 | 0.001 | | Creatinine (mg/dl) | .95 ± 0.3 | 1.01 ± 0.5 | 0.23 | | Urine Alb: Creat Ratio (mg/g creatinine) | 44.43 ± 73.0 | 48.14 ± 78.2 | 0.82 | | AST (IU/L) | 32.13 ± 16.6 | 31.65 ± 22.1 | 0.82 | | ALT (IU/L) | 38.75 ± 28.1 | 40.41 ± 31.7 | 0.59 | | S. Cholesterol (mg/dl) | 180.42 ± 43.0 | 185.17 ± 44.6 | 0.28 | | S. Triglycerides (mg/dl) | 127.81 ± 52.3 | 135.96 ± 81.5 | 0.30 | | HDL (mg/dl) | 48.56 ± 13.2 | 46.08 ± 14.5 | 0.08 | | LDL (mg/dl) | 106.30 ± 38.9 | 111.77 ± 39.9 | 0.165 | | HbA1c (%) | 8.60 ± 2.0 | 8.62 ± 2.3 | 0.93 | | FBS (mg/dl) | 171.71 ± 65.5 | 180.08 ± 72.7 | 0.24 | | PPBS (mg/dl) | 258.51 ± 109.8 | 268.85 ± 112.1 | 0.35 | | Uric Acid (mg/dl) | 4.71 ± 1.3 | 4.80 ± 1.4 | 0.53 | | eGFR (ml/hr) | 83.86 ± 26.9 | 89.09 ± 46.4 | 0.24 |
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(b) Comparison of clinical and biochemical parameters between clinical hypothyroid and euthyroid patients (nominal variables) |
| | Parameters | Hypothyroid (Clinical) (n=113) | Euthyroid
(n=971) | P Value | | N (%) | N (%) |
| | Sex (M) | 41 (36.2) | 701 (67.5) | <0.001 | | Sex (F) | 72 (63.7) | 338 (32.5) | | Smoker | 3 (2.6) | 81 (7.8) | 0.054 | | Alcohol | 9 (7.9) | 174 (16.7) | 0.014 | | Duration > 2 yrs | 80 (70.8) | 625 (60.1) | 0.032 | | Hypertension | 48 (42.5) | 307 (29.5) | 0.005 | | Dyslipidemia | 51 (45.1) | 265 (25.5) | <0.001 | | Systolic BP> 130 mm of hg | 68 (60.2) | 602 (57.9) | 0.58 | | Diastolic BP > 90 mm of hg | 15 (13.3) | 157 (15.1) | 0.62 | | Abdominal obesity | 107 (94.7) | 952 (91.6) | 0.22 | | Anemia | 55 (48.7) | 252 (24.2) | <0.001 | | ESR > 20 mm/hr | 54 (47.8) | 336 (32.3) | 0.002 | | e-GFR <90 ml/min | 16 (14.1) | 172 (16.5) | 0.49 | | Urine Alb: creat Ratio> 30mg/g | 36 (31.9) | 301 (29.0) | 0.54 | | LDL > 100 mg/dl | 59 (52.2) | 591 (56.9) | 0.34 | | HbA1C > 7 % | 87 (77.0) | 744 (71.6) | 0.23 | | FBS > 110 mg% | 93 (82.3) | 871 (83.8) | 0.68 | | PPBS > 140 mg% | 95 (84.1) | 868 (83.5) | 0.89 | | Hyperuricemia | 41 (36.3) | 427 (41.1) | 0.33 | | Overweight/obese | 101 (89.4) | 823 (79.2) | 0.015 | | Obese | 56 (49.6) | 415 (39.9) | 0.06 |
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