Nonsteroidal Anti-Inflammatory Drugs for Wounds: Pain Relief or Excessive Scar Formation?

Table 1

The levels of PGE2 and TGF-beta during the normal and aberrant wound healing process.

	Normal Healing Process			Excessive Scarring
Phases	1${}^{*}$	2	3	1	2	3
TGF-beta	↑	↑	↓	↑	↑↑↑	↑↑
PGE2	↑	↑	↑	↑	↓ ↓↓	↓ ↓
Net Effect	debrided	limited	mature	unknown	excessive	delayed

${}^{*}$1 for inflammatory phase, 2 for proliferative phase, and 3 for remodeling phase.