Morinda citrifolia (Noni) Fruit Juice Reduces Inflammatory Cytokines Expression and Contributes to the Maintenance of Intestinal Mucosal Integrity in DSS Experimental Colitis

Figure 2

Noni fruit juice consumption preserves intestinal architecture in a dose-dependent manner. C57BL/6 mice were exposed to dextran sulfate sodium (DSS) 2.5% and treated daily with noni fruit juice. The colon was collected on day 9 for histopathological analysis. (a) Healthy mice without colitis; (b) mice exposed to DSS: lamina propria with moderate edema and mononuclear cell infiltration (arrowhead), submucosa with moderate mononuclear infiltrate and severe edema (arrow); (c) mice exposed to DSS and treated with pure noni fruit juice: lamina propria with moderate edema (arrow) and mononuclear infiltrate (arrowhead); (d) mice exposed to DSS and treated with noni fruit juice diluted 1 : 10: crypts with preserved irregularities (asterisk); lamina propria with moderate edema (arrow) and mononuclear infiltrate (arrowhead); (e) mice exposed to DSS and treated with noni fruit juice diluted 1 : 100: regular and atrophic crypts (asterisk); lamina propria with moderate edema (arrow) and mononuclear infiltrate (arrowhead).

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