Clinical Study
Assessment of Definitions of Sustained Disease Progression in Relapsing-Remitting Multiple Sclerosis
Table 2
Patients who met each definition of sustained progression during followup.
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Patients with sustained progression |
Patient with sustained progression and subsequent visits |
Patients who always progressed among those with subsequent visits | | Number | Percent of all patients | Number | Percent of those with sustained progression | Number | Percent of those with subsequent visits |
| EDSS | | | | | | | (D1) Increase of 0.5 | 392 | 42.2 | 315 | 80.4 | 137 | 43.5 | (D2) Increase of 1 | 278 | 29.9 | 225 | 80.9 | 98 | 43.6 | (D3) Increase of 1.5 | 147 | 15.8 | 120 | 81.6 | 61 | 50.8 | (D4) Increase of 1/increase 1.5 for baseline EDSS = 0 | 212 | 22.8 | 169 | 79.7 | 73 | 43.2 | Functional system | | | | | | | (D5) Pyramidal function | 217 | 23.4 | 179 | 82.5 | 53 | 29.6 | (D6) Cerebellar function | 120 | 12.9 | 94 | 78.3 | 29 | 30.9 | (D7) Brainstem function | 89 | 9.6 | 62 | 69.7 | 13 | 21 | (D8) Sensory function | 271 | 29.2 | 226 | 83.4 | 75 | 33.2 | (D9) Bowel bladder function | 179 | 19.3 | 135 | 75.4 | 38 | 28.1 | (D10) Mental function | 161 | 17.3 | 112 | 69.6 | 40 | 35.7 | (D11) Visual function | 91 | 9.8 | 73 | 80.2 | 16 | 21.9 | Combination of functional system | | | | | | | (D12) Any FS | 536 | 57.7 | 433 | 80.8 | 228 | 52.7 | (D13) First FS | 536 | 57.7 | 433 | 80.8 | 122 | 28.2 | (D14) Sum of subscales increase of 2 | 243 | 26.2 | 187 | 77 | 85 | 45.5 | (D15) Sum of subscales increase of 3 | 148 | 15.9 | 111 | 75 | 49 | 44.1 |
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A total of 929 patients contributed to the analysis. EDSS: expanded disability status scale.
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