Neuromuscular Junction Protection for the Potential Treatment of Amyotrophic Lateral Sclerosis
Figure 1
Schematic illustrating the “Dying-Back” hypothesis. (a) In a healthy system, communication and the transport of vital biomolecules occurs normally along the axon connecting MNs and the NMJs they innervate. (b) In ALS, a progressive distal to proximal degeneration occurs, described as “Dying-Back.” NMJ degeneration is followed by axonal degeneration and eventually MN degeneration.
