Regional Differences in Susceptibility to Hypoxic-Ischemic Injury in the Preterm Brain: Exploring the Spectrum from White Matter Loss to Selective Grey Matter Injury in a Rat Model

Table 1

Summary and comparison of study animal characteristics by hypoxia time.

Characteristics	Controls 𝑛=10	1 hr 0 min 𝑛=10	1 hr 5 min 𝑛=9	1 hr 10 min 𝑛=8	1 hr 15 min 𝑛=11	1 hr 20 min 𝑛=11
Postnatal day at study start/surgery	6	6	6	6	6	6
Postnatal day at sacrifice	9	9	9	9	9	9
Mean weight at PD 6, grams ± SEM	13.19±0.45	13.61±0.36	13.67±0.32	14.08±1.35	13.45±0.67	13.19±0.33
Mean weight at PD 9, grams ± SEM	19.53±0.63	19.20±0.46	19.70±0.35	20.07±0.34	19.78±0.26	19.08±0.40
Mean weight gain, grams ± SEM	6.34±0.33	5.59±0.27	6.03±0.20	6.01±0.21	6.33±0.16	5.9±0.20
Surgery time, min ± SEM	N/A	6.83±1.38	9.33±0.88	8.56±0.73	10.18±0.77	7.2±0.64
Mean core temperature at surgery start, Celsius ± SEM	N/A	36.13±0.40	35.2±0.25	34.90±0.18	34.90±0.25	34.80±0.40
Mean core temperature at surgery end, Celsius ± SEM	N/A	33.28±0.62	31.9±0.20	32.20±0.32	32.20±0.42	32.00±0.28
Temperature decrease during surgery, Celsius ± SEM	N/A	2.9±0.31	3.3±0.25	3.0±0.33	2.9±0.56	2.8±0.45

SEM: standard error of mean.
PD: postnatal day.