Large D-Dimer Fluctuation in Normal Pregnancy: A Longitudinal Cohort Study of 4,117 Samples from 714 Healthy Danish Women

Table 1

Gestational age-specific D-dimer reference intervals.

	2.5th percentile; (90% CI)	97.5th percentile; (90% CI)	Samples ()	Outliers ()
1st trimester; Gestational weeks <15	0.2; (0.2-0.2)	0.9; (0.8–0.9)	222	13
2nd trimester; Gestational weeks 15–27	0.2; (0.2-0.2)	1.5; (1.4–1.6)	1412	12
3rd trimester; Gestational weeks >27	0.4; (0.4–0.5)	2.8; (2.6–3.1)	971	20

The 2.5th and 97.5th percentiles (bold) with 90% confidence intervals (in brackets) are given. Outliers were removed using Horn’s algorithm with a fence factor of 1.5.