Mouse Models of Prostate Cancer

Table 1

Prostate cancer mouse models utilizing T antigen.

Model	Year	Other tissues affected	Metastasis sites	Cell of origin	Castration resistance	References
C3(1)-Tag	1994	Mammary gland, testes, salivary gland	Infrequently to the lung	Epithelial	Not determined	[94, 95]
PB-T/tag (TRAMP)	1995	None	LN, lung	Neuroendocrine	Yes	[96–100]
FG-Tag	1996	Adrenal gland, adipose tissue	LN, adrenal glands, kidneys	Neuroendocrine	Yes	[102–104, 106]
LPB-Tag (LADY)	1998	None	LN, liver, lung	Neuroendocrine	No	[107–109]
CR2-Tag	1998	Paneth (intestinal epithelial) cells	LN, lung, liver, bone marrow	Neuroendocrine	Yes	[115–117]
PSP94-T/tag (TGMAP & KIMAP)	2002	None	LN, kidney	Epithelial & rarely neuroendocrine	Yes	[118–120]
LPB-Tag/ARR2 PB-hepsin	2004	None	Lung, liver, bone	Neuroendocrine	Not determined	[113]