Review Article
Mouse Models of Prostate Cancer
Table 1
Prostate cancer mouse models utilizing T antigen.
| Model | Year | Other tissues affected | Metastasis sites | Cell of origin | Castration resistance | References |
| C3(1)-Tag | 1994 | Mammary gland, testes, salivary gland | Infrequently to the lung | Epithelial | Not determined | [94, 95] | PB-T/tag (TRAMP) | 1995 | None | LN, lung | Neuroendocrine | Yes | [96–100] | FG-Tag | 1996 | Adrenal gland, adipose tissue | LN, adrenal glands, kidneys | Neuroendocrine | Yes | [102–104, 106] | LPB-Tag (LADY) | 1998 | None | LN, liver, lung | Neuroendocrine | No | [107–109] | CR2-Tag | 1998 | Paneth (intestinal epithelial) cells | LN, lung, liver, bone marrow | Neuroendocrine | Yes | [115–117] | PSP94-T/tag (TGMAP & KIMAP) | 2002 | None | LN, kidney | Epithelial & rarely neuroendocrine | Yes | [118–120] | LPB-Tag/ARR2 PB-hepsin | 2004 | None | Lung, liver, bone | Neuroendocrine | Not determined | [113] |
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