Mouse Models of Prostate Cancer

Table 4

Conditional knockout models.

Model	Year	Other tissues affected	Highest stage of neoplasia	Castration resistance	References
PSA^CreNkx3.1^flox	2002	None	PIN	Not determined	[176]
PSA^CrePten^flox	2005	None	Infrequent LN metastasis	No	[177]
PB^Cre4Pten^flox	2003	None	LN & lung metastasis	Yes	[178, 179]
PB^CreRb^flox	2004	None	Hyperplasia	Not determined	[180, 181]
PB^Cre4LSL-Ph15LO-1 (FLiMP)	2006	None	PIN	Not determined	[182]
PB^Cre4p53^floxRb^flox	2006	None	LN, lung, liver & adrenal glands metastasis	Yes	[180, 181]
PB^Cre4Apc^flox	2007	None	Adenocarcinoma	Yes	[183]
PB^Cre4IGF-1^flox	2008	None	Hyperplasia	No	[184]
PB^Cre4Catnb^lox(ex3); K-ras^LSLV12	2009	Bulbourethral gland, preputial gland, and urethral gland metaplasias, testes	Adenocarcinoma	Putative	[185]
PB^Cre4Catnb^lox(ex3) & Nkx3.1^CreCatnb^lox(ex3)	2009	None	HGPIN	Yes	[186]
PB^Cre4Brca2^floxp53^flox	2010	None	HGPIN	Yes	[187]
MMTV^CreCatnb^lox(ex3)	2003	Skin, salivary glands, epididymis, vas deferens, seminal vesicle, spleen, mammary tissue	Hyperplasia & metaplasia	No	[188]
MMTV^CrePten^flox	2004	Mammary tissue, skin, lymphocytes, oocytes, seminal vesicles, salivary glands	HGPIN	No	[189]
FSP1^CreTGFβ ^flox	2004	Fibroblasts, particularly in skin and stomach	PIN	Not determined	[190]
Nkx3.1^CreERT2Pten^flox	2009	Unknown	Adenocarcinoma	Yes	[16]