Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor

Figure 3

Action mechanisms of PPARγ as a tumor promoter. ACLY, ATP citrate lyase; MIG12, midline-1-interacting G12-like protein; FASN, fatty acid synthase; NR1D1, Rev-ErbAα; KLF4, Krüppel-Like Factor 4; ALDH, aldehyde dehydrogenase; Nox1, NADPH oxidase 1; ROS, reactive oxygen species; VEGF, vascular endothelial growth factor.