Review Article

Crosstalk between MicroRNAs and Peroxisome Proliferator-Activated Receptors and Their Emerging Regulatory Roles in Cardiovascular Pathophysiology

Figure 3

The regulatory function of microRNAs/peroxisome proliferator-activated receptors (PPARs) axis in cardiomyocyte apoptosis, and cardiac remodeling and dysfunction. CKD: chronic kidney disease; TGF-β1: transforming growth factor β1; I/R: ischemia/reperfusion; Akt: serine/threonine kinase 1; Mcl-1: myeloid leukaemia cell differentiation protein-1; Mcl-2: an anti-apoptotic Bcl-2 family member; MEF2D: myocyte enhancer factor 2D. CM: cardiac myxoma.